Package: admixr2
Type: Package
Title: Aggregate Data Modelling
Version: 0.3.0
Authors@R: c(
        person("H.", "van de Beek", email = "h.van.de.beek@lacdr.leidenuniv.nl", role = c("aut", "cre")),
        person("P.A.J.", "Välitalo", role = "aut"),
        person("L.B.", "Zwep", role = "aut"),
        person("J.G.C.", "van Hasselt", role = "aut")
    )
Description: Fit pharmacokinetic/pharmacodynamic (PK/PD) models to
        aggregate-level data (mean vector and covariance matrix per
        study) rather than individual-level data, for meta-analysis
        across studies. Integrates with the 'nlmixr2'/'rxode2'
        ecosystem via four estimation methods: a First-Order ('FO')
        analytical estimator, a Monte Carlo (MC) estimator, a
        Gauss-Hermite quadrature ('GH') estimator, and an Iterative
        Reweighting Monte Carlo ('IRMC') estimator. Methods are based
        on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software
        described in van de Beek et al. (2025)
        <doi:10.1007/s10928-025-10011-w>.
License: GPL (>= 3)
URL: https://leidenpharmacology.github.io/admixr2,
        https://github.com/LeidenPharmacology/admixr2
BugReports: https://github.com/LeidenPharmacology/admixr2/issues
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.1.0)
Roxygen: list(markdown = TRUE)
Imports: checkmate, digest, nlmixr2est (>= 6.0.1), nloptr, qs2,
        randtoolbox, Rcpp, rxode2 (>= 5.1.2), symengine
LinkingTo: Rcpp, RcppEigen
Suggests: expm, ggplot2, knitr, MASS, memuse, mirai, mnormt, nlmixr2
        (>= 5.0.0), nlmixr2data, patchwork, rmarkdown, testthat (>=
        3.0.0)
VignetteBuilder: knitr
Config/testthat/edition: 3
Config/roxygen2/version: 8.0.0
Config/pak/sysreqs: cmake libgmp3-dev make libmpfr-dev
Repository: https://leidenpharmacology.r-universe.dev
Date/Publication: 2026-07-17 12:52:30 UTC
RemoteUrl: https://github.com/leidenpharmacology/admixr2
RemoteRef: HEAD
RemoteSha: efaac7f61386681290ce590fefd01b74534c2bd0
NeedsCompilation: yes
Packaged: 2026-07-17 15:09:40 UTC; root
Author: H. van de Beek [aut, cre],
  P.A.J. Välitalo [aut],
  L.B. Zwep [aut],
  J.G.C. van Hasselt [aut]
Maintainer: H. van de Beek <h.van.de.beek@lacdr.leidenuniv.nl>