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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "admixr2" in publications use:'
type: software
license: GPL-3.0-or-later
title: 'admixr2: Aggregate Data Modelling'
version: 0.1.0
doi: 10.1007/s10928-025-10011-w
identifiers:
- type: doi
  value: 10.32614/CRAN.package.admixr2
abstract: 'Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data
  (mean vector and covariance matrix per study) rather than individual-level data.
  Integrates with the ''nlmixr2''/''rxode2'' ecosystem via three estimation methods:
  a First-Order (''FO'') analytical estimator, a Monte Carlo (MC) estimator, and an
  Iterative Reweighting Monte Carlo (''IRMC'') estimator. Methods are based on Välitalo
  (2021) <https://doi.org/10.1007/s10928-021-09760-1>; software described in van de
  Beek et al. (2025) <https://doi.org/10.1007/s10928-025-10011-w>.'
authors:
- family-names: Beek
  given-names: H.
  name-particle: van de
  email: h.van.de.beek@lacdr.leidenuniv.nl
- family-names: Välitalo
  given-names: P.A.J.
- family-names: Zwep
  given-names: L.B.
- family-names: Hasselt
  given-names: J.G.C.
  name-particle: van
preferred-citation:
  type: article
  title: 'Aggregate data modelling: A fast implementation for fitting pharmacometrics
    models to summary-level data in R'
  authors:
  - family-names: Beek
    given-names: Hidde
    name-particle: van de
  - family-names: Välitalo
    given-names: Pyry A. J.
  - family-names: Hasselt
    given-names: J. G. Coen
    name-particle: van
  - family-names: Zwep
    given-names: Laura B.
  journal: Journal of Pharmacokinetics and Pharmacodynamics
  year: '2025'
  volume: '53'
  issue: '1'
  doi: 10.1007/s10928-025-10011-w
  start: '3'
repository: https://leidenpharmacology.r-universe.dev
repository-code: https://github.com/LeidenPharmacology/admixr2
commit: 4e62702f707c348211599c3d939b0aa3c3cbc27b
url: https://leidenpharmacology.github.io/admixr2/
date-released: '2026-05-29'
contact:
- family-names: Beek
  given-names: H.
  name-particle: van de
  email: h.van.de.beek@lacdr.leidenuniv.nl
references:
- type: article
  title: Pharmacometric estimation methods for aggregate data, including data simulated
    from other pharmacometric models
  authors:
  - family-names: Välitalo
    given-names: Pyry Antti Juhana
  journal: Journal of Pharmacokinetics and Pharmacodynamics
  year: '2021'
  volume: '48'
  issue: '5'
  doi: 10.1007/s10928-021-09760-1
  start: '623'
  end: '638'