{
  "_id": "6a2266c9cd65a98ecbd4559d",
  "Package": "admixr2",
  "Type": "Package",
  "Title": "Aggregate Data Modelling",
  "Version": "0.1.0",
  "Authors@R": "c(\nperson(\"H.\", \"van de Beek\", email = \"h.van.de.beek@lacdr.leidenuniv.nl\", role = c(\"aut\", \"cre\")),\nperson(\"P.A.J.\", \"Välitalo\", role = \"aut\"),\nperson(\"L.B.\", \"Zwep\", role = \"aut\"),\nperson(\"J.G.C.\", \"van Hasselt\", role = \"aut\")\n)",
  "Description": "Fit pharmacokinetic/pharmacodynamic (PK/PD) models to\naggregate-level data (mean vector and covariance matrix per\nstudy) rather than individual-level data. Integrates with the\n'nlmixr2'/'rxode2' ecosystem via three estimation methods: a\nFirst-Order ('FO') analytical estimator, a Monte Carlo (MC)\nestimator, and an Iterative Reweighting Monte Carlo ('IRMC')\nestimator. Methods are based on Välitalo (2021)\n<doi:10.1007/s10928-021-09760-1>; software described in van de\nBeek et al. (2025) <doi:10.1007/s10928-025-10011-w>.",
  "License": "GPL (>= 3)",
  "URL": "https://leidenpharmacology.github.io/admixr2/,\nhttps://github.com/LeidenPharmacology/admixr2",
  "BugReports": "https://github.com/LeidenPharmacology/admixr2/issues",
  "Encoding": "UTF-8",
  "LazyData": "true",
  "Roxygen": "list(markdown = TRUE)",
  "RoxygenNote": "7.3.3",
  "VignetteBuilder": "knitr",
  "Config/testthat/edition": "3",
  "Config/pak/sysreqs": "cmake libgmp3-dev make libmpfr-dev",
  "Repository": "https://leidenpharmacology.r-universe.dev",
  "Date/Publication": "2026-05-29 12:05:12 UTC",
  "RemoteUrl": "https://github.com/leidenpharmacology/admixr2",
  "RemoteRef": "HEAD",
  "RemoteSha": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
  "NeedsCompilation": "yes",
  "Packaged": {
    "Date": "2026-06-03 09:44:56 UTC",
    "User": "root"
  },
  "Author": "H. van de Beek [aut, cre],\nP.A.J. Välitalo [aut],\nL.B. Zwep [aut],\nJ.G.C. van Hasselt [aut]",
  "Maintainer": "H. van de Beek <h.van.de.beek@lacdr.leidenuniv.nl>",
  "MD5sum": "783175239ffb90e4c5eb5aa7b7acb301",
  "_user": "leidenpharmacology",
  "_type": "src",
  "_file": "admixr2_0.1.0.tar.gz",
  "_fileid": "1f5911595e1843943e63cf3b0bacb72f92fb88427cb98cb4d31924e26d8fdd85",
  "_filesize": 609502,
  "_sha256": "1f5911595e1843943e63cf3b0bacb72f92fb88427cb98cb4d31924e26d8fdd85",
  "_created": "2026-06-03T09:44:56.000Z",
  "_published": "2026-06-05T06:03:53.704Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 79672843657,
      "time": 190,
      "config": "linux-devel-arm64",
      "r": "4.7.0",
      "check": "FAIL",
      "artifact": ""
    },
    {
      "job": 79672843545,
      "time": 164,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "FAIL",
      "artifact": ""
    },
    {
      "job": 79672843697,
      "time": 219,
      "config": "linux-release-arm64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7381201450"
    },
    {
      "job": 79672843852,
      "time": 209,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7381195947"
    },
    {
      "job": 79672843880,
      "time": 200,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7381183278"
    },
    {
      "job": 79672843833,
      "time": 917,
      "config": "macos-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7381450559"
    },
    {
      "job": 79672843710,
      "time": 189,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7381178907"
    },
    {
      "job": 79672843773,
      "time": 324,
      "config": "macos-release-x86_64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7381233958"
    },
    {
      "job": 79672843485,
      "time": 361,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7381114105"
    },
    {
      "job": 79672843885,
      "time": 172,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7381181463"
    },
    {
      "job": 79672843866,
      "time": 806,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "7381433342"
    },
    {
      "job": 79672843952,
      "time": 837,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7381443925"
    },
    {
      "job": 79672843774,
      "time": 795,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7381427997"
    }
  ],
  "_buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/leidenpharmacology/admixr2",
  "_commit": {
    "id": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
    "author": "hiddevandebeek <beekh@vuw.leidenuniv.nl>",
    "committer": "hiddevandebeek <beekh@vuw.leidenuniv.nl>",
    "message": "initial release admixr2\n",
    "time": 1780056312
  },
  "_maintainer": {
    "name": "H. van de Beek",
    "email": "h.van.de.beek@lacdr.leidenuniv.nl"
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.1.0",
      "role": "Depends"
    },
    {
      "package": "Rcpp",
      "role": "LinkingTo"
    },
    {
      "package": "RcppEigen",
      "role": "LinkingTo"
    },
    {
      "package": "checkmate",
      "role": "Imports"
    },
    {
      "package": "digest",
      "role": "Imports"
    },
    {
      "package": "nlmixr2est",
      "role": "Imports"
    },
    {
      "package": "nloptr",
      "role": "Imports"
    },
    {
      "package": "qs2",
      "role": "Imports"
    },
    {
      "package": "randtoolbox",
      "role": "Imports"
    },
    {
      "package": "Rcpp",
      "role": "Imports"
    },
    {
      "package": "rxode2",
      "role": "Imports"
    },
    {
      "package": "expm",
      "role": "Suggests"
    },
    {
      "package": "furrr",
      "role": "Suggests"
    },
    {
      "package": "future",
      "role": "Suggests"
    },
    {
      "package": "ggplot2",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "mnormt",
      "role": "Suggests"
    },
    {
      "package": "nlmixr2",
      "role": "Suggests"
    },
    {
      "package": "patchwork",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    }
  ],
  "_owner": "leidenpharmacology",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2026-22",
      "n": 1
    }
  ],
  "_tags": [
    {
      "name": "v0.1.0",
      "date": "2026-05-29"
    }
  ],
  "_stars": 0,
  "_contributors": [
    {
      "user": "hiddevandebeek",
      "count": 1,
      "uuid": 79250134
    }
  ],
  "_userbio": {
    "uuid": 262559512,
    "type": "organization",
    "name": "LeidenPharmacology"
  },
  "_downloads": {
    "count": 0,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/admixr2"
  },
  "_devurl": "https://github.com/leidenpharmacology/admixr2",
  "_pkgdown": "https://leidenpharmacology.github.io/admixr2/",
  "_topics": [
    "cpp"
  ],
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/admixr2.html",
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/leidenpharmacology/admixr2",
  "_realowner": "leidenpharmacology",
  "_cranurl": true,
  "_releases": [
    {
      "version": "0.1.0",
      "date": "2026-06-02"
    }
  ],
  "_exports": [
    "adfoControl",
    "adirmcControl",
    "admControl",
    "admData",
    "admStopWorkers",
    "datagen",
    "datagenControl"
  ],
  "_datasets": [
    {
      "name": "examplomycin",
      "title": "Examplomycin dataset",
      "object": "examplomycin",
      "class": [
        "data.frame"
      ],
      "fields": [
        "ID",
        "TIME",
        "DV",
        "AMT",
        "EVID",
        "CMT"
      ],
      "rows": 5000,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "adfoControl",
      "title": "Control settings for the FO (First-Order) estimator",
      "topics": [
        "adfoControl"
      ]
    },
    {
      "page": "adirmcControl",
      "title": "Control settings for the IRMC estimator",
      "topics": [
        "adirmcControl"
      ]
    },
    {
      "page": "admControl",
      "title": "Control settings for the ADM estimator",
      "topics": [
        "admControl"
      ]
    },
    {
      "page": "admData",
      "title": "Dummy data frame for nlmixr2 dispatch",
      "topics": [
        "admData"
      ]
    },
    {
      "page": "admStopWorkers",
      "title": "Stop PSOCK workers",
      "topics": [
        "admStopWorkers"
      ]
    },
    {
      "page": "datagen",
      "title": "Generate aggregate study data from (possibly different) pharmacometric models",
      "topics": [
        "datagen"
      ]
    },
    {
      "page": "datagenControl",
      "title": "Control parameters for 'datagen()'",
      "topics": [
        "datagenControl"
      ]
    },
    {
      "page": "examplomycin",
      "title": "Examplomycin dataset",
      "topics": [
        "examplomycin"
      ]
    },
    {
      "page": "nlmixr2Est.adfo",
      "title": "Fit an aggregate data model via First-Order (FO) approximation",
      "topics": [
        "nlmixr2Est.adfo"
      ]
    },
    {
      "page": "nlmixr2Est.adirmc",
      "title": "Fit an aggregate data model via Iterative Reweighting MC (adirmc estimator)",
      "topics": [
        "nlmixr2Est.adirmc"
      ]
    },
    {
      "page": "nlmixr2Est.admc",
      "title": "Fit an aggregate data model via Monte Carlo (admc estimator)",
      "topics": [
        "nlmixr2Est.admc"
      ]
    },
    {
      "page": "plot.admFit",
      "title": "Diagnostic plots for an admixr2 fit",
      "topics": [
        "plot.admFit"
      ]
    },
    {
      "page": "print.admFit",
      "title": "Print method for admFit objects",
      "topics": [
        "print.admFit"
      ]
    }
  ],
  "_pkglogo": "https://github.com/leidenpharmacology/admixr2/raw/HEAD/man/figures/logo.png",
  "_readme": "https://github.com/leidenpharmacology/admixr2/raw/HEAD/README.md",
  "_rundeps": [
    "armadillo4r",
    "backports",
    "BH",
    "cachem",
    "checkmate",
    "cli",
    "cpp11",
    "cpp4r",
    "crayon",
    "data.table",
    "desc",
    "digest",
    "dparser",
    "evaluate",
    "farver",
    "fastmap",
    "ggplot2",
    "glue",
    "gtable",
    "highr",
    "inline",
    "isoband",
    "knitr",
    "labeling",
    "lattice",
    "lbfgsb3c",
    "lifecycle",
    "lotri",
    "Matrix",
    "memoise",
    "minqa",
    "n1qn1",
    "nlme",
    "nlmixr2data",
    "nlmixr2est",
    "nloptr",
    "numDeriv",
    "PreciseSums",
    "qs2",
    "R6",
    "randtoolbox",
    "RColorBrewer",
    "Rcpp",
    "RcppArmadillo",
    "RcppEigen",
    "RcppParallel",
    "rex",
    "rlang",
    "rngWELL",
    "rxode2",
    "rxode2ll",
    "S7",
    "scales",
    "sitmo",
    "StanHeaders",
    "stringfish",
    "symengine",
    "sys",
    "vctrs",
    "viridisLite",
    "withr",
    "xfun",
    "yaml"
  ],
  "_sysdeps": [
    {
      "shlib": "libstdc++",
      "package": "libstdc++6",
      "source": "gcc",
      "version": "14.2.0-4ubuntu2~24.04.1",
      "name": "c++",
      "homepage": "http://gcc.gnu.org/",
      "description": "GNU Standard C++ Library v3"
    }
  ],
  "_vignettes": [
    {
      "source": "admixr2.Rmd",
      "filename": "admixr2.html",
      "title": "Getting started with admixr2",
      "engine": "knitr::rmarkdown",
      "headings": [
        "What is aggregate-data modelling?",
        "The examplomycin dataset",
        "Computing aggregate statistics",
        "Model definition",
        "Assembling the study specification",
        "Fitting",
        "Inspecting the fit",
        "Diagnostic plots"
      ],
      "created": "2026-05-29 12:05:12",
      "modified": "2026-05-29 12:05:12",
      "commits": 1
    }
  ],
  "_score": 3.6989700043360187,
  "_indexed": true,
  "_nocasepkg": "admixr2",
  "_universes": [
    "leidenpharmacology"
  ],
  "_binaries": [
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-06-03T09:48:19.000Z",
      "distro": "noble",
      "arch": "aarch64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "71416c01b3e99d7c8639744ff7ff85f8e79f42c739b85b20471c1637492e6138",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-06-03T09:48:08.000Z",
      "distro": "noble",
      "arch": "x86_64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "2ae254da61cbd8c60863aa156513bf67f62f2dbe37078a4cfabf351f064abe28",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-06-03T09:47:54.000Z",
      "arch": "aarch64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "fa40774d81db1caddca11e3aa48f17193c71a3c693cea06454f9a233b8f1c779",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-06-03T09:56:52.000Z",
      "arch": "x86_64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "fe7f46d9c3d905db018dfc48b3d841569dbddf0d53a1d7e14bf847c4b1b9c0fb",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-06-03T09:47:26.000Z",
      "arch": "aarch64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "75fddc81130d9684af1d9f1e3ae339f9bd6e82290c23de67c2beb1dfdff03053",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-06-03T09:48:47.000Z",
      "arch": "x86_64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "b8b23e1c0d8d187197c4f01884e61c112523e2a6076c15025fc9a5c270382e63",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.1.0",
      "date": "2026-06-03T09:48:17.000Z",
      "arch": "emscripten",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "105a89e5e9d8678df201c19a631537be8032ddb5ee5110bdd98f33bcc320dd2a",
      "status": "success",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-06-03T09:57:25.000Z",
      "arch": "x86_64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "ee29a4fc73231708edc44772e8470069abd8a47472e041c9e10197408a8dc877",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-06-03T09:57:46.000Z",
      "arch": "x86_64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "0c97659191d0d6bae6dffe4705a86d8a088432dc7acae79f8d09d715a1221a3c",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-06-03T09:57:14.000Z",
      "arch": "x86_64",
      "commit": "4e62702f707c348211599c3d939b0aa3c3cbc27b",
      "fileid": "c4b0acb7d4ab2f9f19cff1a30f481b6ec1a47023891a52606cb53ae09f33a839",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/leidenpharmacology/actions/runs/26876518713"
    }
  ]
}