admixr2 - Aggregate Data Modelling
Fit pharmacokinetic/pharmacodynamic (PK/PD) models to
aggregate-level data (mean vector and covariance matrix per
study) rather than individual-level data. Integrates with the
'nlmixr2'/'rxode2' ecosystem via three estimation methods: a
First-Order ('FO') analytical estimator, a Monte Carlo (MC)
estimator, and an Iterative Reweighting Monte Carlo ('IRMC')
estimator. Methods are based on Välitalo (2021)
<doi:10.1007/s10928-021-09760-1>; software described in van de
Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
