What is aggregate-data modelling? | The examplomycin dataset | Computing aggregate statistics | Model definition | Assembling the study specification | Fitting | Inspecting the fit | Diagnostic plots | Where to next
Package: admixr2 0.4.1
H. van de Beek
admixr2: Aggregate Data Modelling
Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data, for meta-analysis across studies. Integrates with the 'nlmixr2'/'rxode2' ecosystem via four estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, a Gauss-Hermite quadrature ('GH') estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
Authors:
admixr2_0.4.1.tar.gz
admixr2_0.4.1.zip(r-4.7-x86_64)admixr2_0.4.1.zip(r-4.7-arm64)admixr2_0.4.1.zip(r-4.6-x86_64)admixr2_0.4.1.zip(r-4.6-arm64)admixr2_0.4.1.zip(r-4.5-x86_64)
admixr2_0.4.1.tgz(r-4.6-x86_64)admixr2_0.4.1.tgz(r-4.6-arm64)admixr2_0.4.1.tgz(r-4.5-x86_64)admixr2_0.4.1.tgz(r-4.5-arm64)
admixr2_0.4.1.tar.gz(r-4.7-arm64)admixr2_0.4.1.tar.gz(r-4.7-x86_64)admixr2_0.4.1.tar.gz(r-4.6-arm64)admixr2_0.4.1.tar.gz(r-4.6-x86_64)
admixr2_0.4.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
admixr2/json (API)
| # Install 'admixr2' in R: |
| install.packages('admixr2', repos = c('https://leidenpharmacology.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/leidenpharmacology/admixr2/issues
Pkgdown/docs site:https://leidenpharmacology.github.io
Datasets:
- examplomycin - Examplomycin dataset
meta-analysispharmacodynamicspharmacokineticspharmacometricscpp
Last updated from:c27e6d9f92. Checks:13 NOTE, 2 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-arm64 | NOTE | 275 | ||
| linux-devel-x86_64 | NOTE | 279 | ||
| source / vignettes | OK | 362 | ||
| linux-release-arm64 | NOTE | 288 | ||
| linux-release-x86_64 | NOTE | 310 | ||
| macos-release-arm64 | NOTE | 225 | ||
| macos-release-x86_64 | NOTE | 525 | ||
| macos-oldrel-arm64 | NOTE | 183 | ||
| macos-oldrel-x86_64 | NOTE | 436 | ||
| windows-devel-arm64 | NOTE | 754 | ||
| windows-devel-x86_64 | NOTE | 301 | ||
| windows-release-arm64 | NOTE | 689 | ||
| windows-release-x86_64 | NOTE | 389 | ||
| windows-oldrel-x86_64 | NOTE | 347 | ||
| wasm-release | OK | 175 |
Exports:adfoControladghControladirmcControladmControladmDataadmMomentsadmPopulationadmStopWorkersadmStudiesadmStudycovDistcovDrawcovStratadatagendatagenControl
Dependencies:armadillo4rbackportsBHcachemcheckmateclicpp11cpp4rcrayondata.tabledigestdparserevaluatefarverfastmapggplot2gluegtablehighrinlineisobandknitrL0Learnlabelinglatticelbfgsb3clifecyclelotrimagrittrMASSMatrixmemoiseminqamirain1qn1nanonextnlmenlmixr2datanlmixr2estnloptrnumDerivplyrPreciseSumsqs2R6randtoolboxRColorBrewerRcppRcppArmadilloRcppEigenRcppParallelRcppTrustreshape2rexrlangrngWELLrxode2rxode2llS7scalessitmoStanHeadersstringfishstringistringrsymenginesysvctrsviridisLitewithrxfunyaml
